Cambridge Graft

Please take a few minutes of your time to complete

the following questionnaire (average time of completion: 3-5 minutes).




A team from Cambridge University is developing next generation, off-the-shelf bioengineered vascular grafts for dialysis treatment. While current grafts have enabled progress in the field of dialysis, improvements are still necessary to reduce further the risk of complications such as infection and blood clotting. The Cambridge team aims to tackle these shortcomings by generating grafts made of densified collagen hydrogel, a cutting-edge biological material in the field of tissue engineering. Similar in makeup to natural blood vessels, the Cambridge graft interacts well with patient’s own tissues and immune system, leading to good healing, low infection rates and low risk of blood clotting. Furthermore, the grafts are fully customisable to address the patient’s needs. The Cambridge team is seeking to demonstrate reductions in surgical complications and therefore improve clinical outcomes for patients.



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1

Which of the following vascular access routes have you used during your treatment?

Select one or more answers
2

Are you satisfied with your current vascular access route? If not, why?

3

If you've selected (c) in Question 2, please explain why. Otherwise, type NA.

4

Have you experienced any of the following vascular access complications?

Select one or more answers
5

Rank the following in terms of importance to you when undergoing dialysis treatment:

Change the order according to your preference (1. - most important, last - least important)
6

Which of the following features do you find interesting about the Cambridge graft?

Select one or more answers
7

Would you be willing to try the Cambridge graft if clinical trials are successful in demonstrating safety and efficacy?

8

Do you regularly follow any technological developments or are you aware of any new grafting materials in vascular access for dialysis?

Select one answer
9

If you've selected (a) or (b) in Question 8, what are they? Otherwise, type NA.

10

When it comes to new vascular access graft technology, how enthusiastic are you about developments in grafting technology?

Select one answer
11

Do you have any concerns about the use of biological cells in graft generation as is the case with other grafting technologies?

Select one answer
12

The Cambridge graft is made of bovine collagen that has already been approved for medical use. Do you have any concerns about the use of bovine collagen as the basis of a graft?

Select one answer
13

If you have concerns (Question 12), please describe. Otherwise, type NA.

14

Based on the information provided, how do you rate the Cambridge graft compared to standard AV access grafts (ePTFE, polyurethane)?

Select one answer
15

Do you have any recommendations to improve any of the existing features or add any additional features to the densified collagen graft? Otherwise, type No.

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